Moussa Djenepo scored his first home goal for Southampton in the 41st minute and Oriol Romeu smacked home a sensational volley with just over 20 minutes remaining as the Saints kept their second clean sheet in two games.
On the Shandong side, Yang Hengyu contributed 16 points, while Qiao Yanzi added 12.
Vinicius added to the conundrum with his winning goal to give Madrid a slightly fortunate win at home to Valladolid on Wednesday, while Jovic has so far failed to impress. Against Levante it will be interesting if Zidane sticks with the Serb or if Vinicius comes back into the side.
The South American zone's 2022 World Cup qualifiers had been scheduled to begin in late March but were postponed because of the coronavirus pandemic. Enditem
The signings of Callum Hudson-Odoi (Chelsea) Sergino Dest (Ajax) failed due to the Blues demand to implement a buying-obligation and Barcelona surpassing Bayern's 20 million offer.
New arrival Pedro Rodriguez scored the winner after the break as the Spaniard unleashed a missile into the net with both power and precision.
"We know that Shanghai boasts a quick pace and three-pointer shooting ability. We had a great defense and restrained the opponents' character today," said Xinjiang coach Gao Fengjuan.
The Schalke coach promised to find a way to develop strategies to revitalize his players' confidence.
Al Nassr broke the deadlock with a penalty in the 35th minute before Abdi Mehdi Qara leveled for Persepolis just six minutes later.
Shanghai guard Peng Szu-Chin hobbled off the court, seemingly through a strain, just one minute into the second half. Without one of its main scorers, Shanghai could not catch up on the offensive end as Xinjiang pulled away through the backcourt combo Wang Siyu and Wang Lili's efforts.
"If you win 4-0, you have to be happy. We will analyse today's game in a couple of days but for now we are delighted. Today it was important to be effective when it mattered most," Union head coach Urs Fischer said.